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Pyridinanaloga als Krebsmedikamente

Pyridinanaloga als Krebsmedikamente

Mitali Naik / Sunil Shingade

51,37 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786208014445
51,37 €
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Sobre IBD

Eine Reihe von N-(3-Cyano-4,6-diphenylpyridin-2-yl)-Heteroaryl-4-carboxamid-Derivaten wurde unter Verwendung von stickstoffhaltigen Heterozyklen synthetisiert. Die Chemie der Reaktionen, die bei der Synthese der Zielverbindungen eingesetzt wurden, sowie die biologischen Eigenschaften werden in dieser Forschungsarbeit diskutiert. Die synthetisierten Verbindungen wurden durch IR-, 1HNMR- und 13CNMR-Spektroskopie zufriedenstellend charakterisiert. Fünf synthetisierte Verbindungen (6a-e) wurden in vitro auf ihre krebshemmende Wirkung gegen die MCF-7-Zelllinie getestet. Die In-vitro-Aktivität basierte auf der MTT-Assay-Methode. Die Ergebnisse der Antikrebsaktivität zeigten, dass unter den getesteten Verbindungen die Verbindung 6d mit einem IC50-Wert von 10 µg am aktivsten war, während die Verbindung 6e mit einem IC50-Wert von 30 µg mäßig aktiv gegen die MCF-7-Zelllinie war.

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