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Analogues de la pyridine comme agents anticancéreux

Analogues de la pyridine comme agents anticancéreux

Mitali Naik / Sunil Shingade

51,37 €
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Editorial:
KS OmniScriptum Publishing
Año de edición:
2024
Materia
Farmacología
ISBN:
9786208014476
51,37 €
IVA incluido
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Une série de dérivés N-(3-cyano-4,6-diphénylpyridin-2-yl)hétéroaryl-4-carboxamide a été synthétisée en utilisant des hétérocycles contenant de l’azote. La chimie des réactions employées dans la synthèse des composés cibles ainsi que les propriétés biologiques sont discutées dans ce travail de recherche. Les composés synthétisés ont été caractérisés de manière satisfaisante par spectroscopie IR, 1HNMR et 13CNMR. Cinq composés synthétisés (6a-e) ont été testés pour leur activité anticancéreuse in vitro contre la lignée cellulaire MCF-7. L’activité in vitro était basée sur la méthode de dosage MTT. Les résultats de l’activité anticancéreuse ont montré que, parmi les composés testés, le composé 6d était le plus actif avec une valeur IC50 de 10 µg, tandis que le composé 6e était modérément actif avec une valeur IC50 de 30 µg contre la lignée cellulaire MCF-7.

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