Rabies is a fatal viral disease transmitted by bites from infected animals, affecting the central nervous system. If not treated promptly, rabies is fatal. Post-exposure treatment, which includes vaccines and immunoglobulins, must be administered immediately after a suspected exposure to prevent progression of the infection. A major obstacle to effective treatment is the blood-brain barrier (BBB), which prevents drugs from reaching the brain. FUS (low-intensity focused ultrasound) offers a promising solution by temporarily opening this barrier to allow treatments to reach the brain. Although this technology is still under development, it could revolutionize emergency rabies treatment. However, prevention, including animal vaccination, remains essential. Further research and investment in this technology is needed to improve access to treatment in high-risk areas.