The book explores desert truffles in detail, highlighting their nutritional and therapeutic importance. It examines their rich nutrient content, medicinal properties and gastronomic uses, as well as their antimicrobial, antioxidant, anticancer and insecticidal activities. The book also explores their culinary uses, highlighting their exceptional taste value. Desert truffles prove to be natural treasures, offering numerous health benefits. Their essential nutritional value, combined with unique bioactive compounds, opens the way to promising medicinal properties, notably as antimicrobial, antioxidant and anticancer agents. Discoveries of new species in Algeria demonstrate the richness of fungal diversity in arid regions, underlining the adaptation of truffles to varied environmental conditions. The book seeks to raise readers’ awareness of the richness and opportunities offered by these fungi, while emphasizing the importance of ongoing research to exploit their full potential.