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Chemical Modulation of Hepcidin in Vertebrates, written by Sandeep Basu, is a comprehensive book that explores the role of the peptide hormone hepcidin in iron homeostasis and its modulation through various chemical means in vertebrates. The book covers a wide range of topics related to iron metabolism and the regulation of hepcidin expression in different physiological and pathological conditions.The book begins by providing an overview of the structure and function of hepcidin and its role in iron regulation. It then delves into the various chemical modulators of hepcidin expression, including iron overload, anemia, inflammation, and hypoxia. The book also covers the regulation of hepcidin expression in the liver, including hepatic dysfunction, inflammation, fibrosis, carcinoma, injury, regeneration, and ischemia-reperfusion.In addition to hepatic regulation, the book also explores the role of hepcidin in non-hepatic tissues, such as inflammatory cytokines, inflammatory bowel disease, cancer, and tumors. The book also covers the various signaling pathways involved in the regulation of hepcidin expression, including the hypoxia-inducible factor, bone morphogenetic protein, signal transducer and activator of transcription 3, Janus kinase 2, nuclear factor erythroid 2, and heme oxygenase 1.Overall, Chemical Modulation of Hepcidin in Vertebrates is a valuable resource for researchers and clinicians interested in understanding the complex regulation of hepcidin in iron homeostasis and its role in various pathological conditions. The book provides a detailed analysis of the molecular mechanisms underlying hepcidin regulation, including transcriptional and post-transcriptional regulation, and the potential therapeutic strategies for modulating hepcidin expression in iron homeostasis disorders.
